Biocatalytic intramolecular cyclopropanation
نویسندگان
چکیده
منابع مشابه
An intramolecular organocatalytic cyclopropanation reaction.
Catalytic processes that form functionalized cyclic molecules represent a key transformation for synthetic organic chemistry. Recently, a number of organocatalytic processes have emerged that often provide excellent levels of both enantioand diastereocontrol for the synthesis of cyclic molecules. Our recent studies have identified the utility of ammonium ylides for carbon–carbon bond formation....
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An efficient method for the asymmetric gold(I)-catalyzed preparation of medium sized rings has been developed. The method provides 7- to 9-membered rings in excellent yield. High enantioselectivities can be achieved for 7- and 8-membered ring products employing chiral gold(I) complexes. The results provide insight into the mechanism, showing the fluxional nature of gold(I)-stabilized vinyl carb...
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Enantioselective α-alkylation of carbonyl is considered as one of the most important processes for asymmetric synthesis. Common alkylation agents, that is, alkyl halides, are notorious substrates for both Lewis acids and organocatalysts. Recently, olefins emerged as a benign alkylating species via photo/radical mechanisms. However, examples of enantioselective alkylation of aldehydes/ketones ar...
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Organic chemists have always been fascinated by the cyclopropane subunit.1 The smallest cycloalkane is found as a basic structural element in a wide range of naturally occurring compounds.2 Moreover, many cyclopropane-containing unnatural products have been prepared to test the bonding features of this class of highly strained cycloalkanes3 and to study enzyme mechanism or inhibition.4 Cyclopro...
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ژورنال
عنوان ژورنال: Nature Catalysis
سال: 2019
ISSN: 2520-1158
DOI: 10.1038/s41929-019-0313-8